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E4f1tm1.1Llca
Targeted Allele Detail
Nomenclature
Symbol: E4f1tm1.1Llca
Name: E4F transcription factor 1; targeted mutation 1.1, Laurent Le Cam
MGI ID: MGI:4867860
Synonyms: E4F1flox
Gene: E4f1  Location: Chr17:24662752-24674366 bp, - strand  Genetic Position: Chr17, 12.39 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:167157
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 4 and a second loxP site followed by an FRT flanked hygromycin thymidine kinase cassette were inserted downstream of exon 14 via homologous recombination. Flp mediated recombination removed the hygromycin thymidine kinase cassette. (J:167157)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any E4f1 Mutation:  26 strains or lines available
References
Original:  J:167157 Lacroix M, et al., Transcription factor E4F1 is essential for epidermal stem cell maintenance and skin homeostasis. Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21076-81
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory