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Tg(Slc32a1-cre)2.1Hzo
Transgene Detail
Nomenclature
Symbol: Tg(Slc32a1-cre)2.1Hzo
Name: transgene insertion 2.1, Huda Y Zoghbi
MGI ID: MGI:4867735
Synonyms: Tg2.1, Viaat-Cre
Transgene: Tg(Slc32a1-cre)2.1Hzo  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation detailsBAC RP23-392P11 containing the Slc32a1 (Viaat) locus was modified by homologous recombination by inserting a Cre-recombinase sequence followed by a stop codon and a polyadenylation sequence downstream of the start codon of the Slc32a1 (or Viaat) gene. After linearization, the BAC only contained Viaat and the truncated coding sequence of the actin-related protein 5 homolog (Actr5) gene. This modified 109 kb BAC was microinjected into fertilized FVB/N oocytes. Transgenic animals have similar expression levels of Slc32a1 and Actr5 to wild type mice. Founder line 2.1 was analyzed and propagated. (J:166851)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Slc32a1     Summary of all recombinase alleles driven by Slc32a1. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:166851 Chao HT, et al., Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes. Nature. 2010 Nov 11;468(7321):263-9
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/11/2018
MGI 6.13
The Jackson Laboratory