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Fbxw7tm1.1Axbe
Targeted Allele Detail
Nomenclature
Symbol: Fbxw7tm1.1Axbe
Name: F-box and WD-40 domain protein 7; targeted mutation 1.1, Axel Behrens
MGI ID: MGI:4867641
Synonyms: Fbxw7f
Gene: Fbxw7  Location: Chr3:84815268-84979198 bp, + strand  Genetic Position: Chr3, 37.7 cM, cytoband E3.3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:166928
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 5 and an additional loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the FRT-flanked neo cassette inserted downstream of exon 5. (J:166928)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fbxw7 Mutation:  38 strains or lines available
References
Original:  J:166928 Hoeck JD, et al., Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun. Nat Neurosci. 2010 Nov;13(11):1365-72
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory