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Transgene Detail
Symbol: Tg(DYRK1A)36Wjs
Name: transgene insertion 36, Woo-Joo Song
MGI ID: MGI:4867514
Synonyms: DYRK1A BAC TG
Transgene: Tg(DYRK1A)36Wjs  Location: unknown  
Strain of Origin:  C57BL/6NCrjBgi
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(DYRK1A)36Wjs expresses 1 gene
Mutation detailsThis transgene consists of a bacterial artificial chromosome clone containing the complete human DYRK1A genomic DNA fragment, including the endogenous promoter (777J19 BAC clone from the RPCI-11 human BAC library). FISH and quantitative PCR analysis shows a single chromosomal integration of the DNA and about a 1.5-fold overexpression of total Dyrk1a (both mouse and human) protein. Two lines 36 and 46 were created, with line 36 entered as the representative line. (J:111293)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:111293 Ahn KJ, et al., DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects. Neurobiol Dis. 2006 Jun;22(3):463-72
All:  3 reference(s)

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MGI 5.21
The Jackson Laboratory