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B3gnt5tm1Big
Targeted Allele Detail
Nomenclature
Symbol: B3gnt5tm1Big
Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5; targeted mutation 1, Darell D Bigner
MGI ID: MGI:4867401
Gene: B3gnt5  Location: Chr16:19760208-19772463 bp, + strand  Genetic Position: Chr16, 12.23 cM, cytoband B1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:166763
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsPart of intron 3 and the coding region of exon 4 were replaced with a neo cassette via homologous recombination. RT-PCR confirmed the absence of expression in multiple tissues in fetal and adult mice. (J:166763)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any B3gnt5 Mutation:  12 strains or lines available
References
Original:  J:166763 Kuan CT, et al., Multiple phenotypic changes in mice after knockout of the B3gnt5 gene, encoding Lc3 synthase--a key enzyme in lacto-neolacto ganglioside synthesis. BMC Dev Biol. 2010;10:114
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory