About   Help   FAQ
Targeted Allele Detail
Symbol: Abl1tm2.2Goff
Name: c-abl oncogene 1, non-receptor tyrosine kinase; targeted mutation 2.2, Stephen P Goff
MGI ID: MGI:4850041
Synonyms: Abldelta
Gene: Abl1  Location: Chr2:31688376-31804227 bp, + strand  Genetic Position: Chr2, 21.86 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:166211
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted at the end of intron 4 and a neo cassette flanked by two loxP sites were inserted into the middle of intron 6. The neo cassette was deleted by transiently transfection of an expression vector of Cre recombinase in the ES cells. Excision of the fifth exon and sixth exon by Cre recombinase deletes part of the tyrosine kinase domain and fully inactivate the gene as determined by Western blot, creating a null allele. (J:166211)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abl1 Mutation:  80 strains or lines available
Original:  J:166211 Qiu Z, et al., Abl family tyrosine kinases are essential for basement membrane integrity and cortical lamination in the cerebellum. J Neurosci. 2010 Oct 27;30(43):14430-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.11
The Jackson Laboratory