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Tg(Igh-TCL1A)1Ypek
Transgene Detail
Nomenclature
Symbol: Tg(Igh-TCL1A)1Ypek
Name: transgene insertion 1, Yuri Pekarsky
MGI ID: MGI:4850003
Synonyms: Emu-TCL1FL
Transgene: Tg(Igh-TCL1A)1Ypek  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Igh-TCL1A)1Ypek expresses 1 gene
 
Mutation detailsA 1.3 kb fragment encoding the entire human TCL1A coding region and both 5' and 3' UTR was placed under the transcriptional control of the mouse Igh-V186.2 promoter and the Igh-mu enhancer sequence. 3'UTR and polyA sequences were derived from the human Beta-globin gene. The Emu enhancer drives B cell-specific expression. Two lines were generated (lines 1 and 4). (J:160184)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:160184 Efanov A, et al., CD5+CD23+ leukemic cell populations in TCL1 transgenic mice show significantly increased proliferation and Akt phosphorylation. Leukemia. 2010 May;24(5):970-5
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory