About   Help   FAQ
The MGI survey is now closed.
Thanks for your support!
Tg(Prnp-SOD1*G37R,-PSEN1)110Dbo
Transgene Detail
Nomenclature
Symbol: Tg(Prnp-SOD1*G37R,-PSEN1)110Dbo
Name: transgene insertion 110, David R Borchelt
MGI ID: MGI:4849838
Transgene: Tg(Prnp-SOD1*G37R,-PSEN1)110Dbo  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x C3H)F2
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Prnp-SOD1*G37R,-PSEN1)110Dbo expresses 2 genes
 
Mutation detailsThe mouse promoter drives neuronal expression of human SOD1 containing the G37R mutation found in patients with familial amyotrophic lateral sclerosis. This transgene was co-injected with Tg(PSEN1)S8-4Dbo. Two lines were generated (39 and 110). (J:104655)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:104655 Wang J, et al., Coincident thresholds of mutant protein for paralytic disease and protein aggregation caused by restrictively expressed superoxide dismutase cDNA. Neurobiol Dis. 2005 Dec;20(3):943-52
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/20/2015
MGI 5.21
The Jackson Laboratory