Tbk1^tm1.1Lex
Targeted Allele Detail

Summary

• Symbol: Tbk1^tm1.1Lex
• Name: TANK-binding kinase 1; targeted mutation 1.1, Lexicon Genetics
• MGI ID: MGI:4847640
• Synonyms: Tbk1^delta
• Gene: Tbk1 Location: Chr10:121382360-121422692 bp, - strand Genetic Position: Chr10, 69.84 cM
• Alliance: Tbk1^tm1.1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166476
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed the neo cassette and exon 2. Western blot analysis confirmed low levels of protein expression in whole cell lysate extracts. Enzymatic assay confirmed that this truncated protein lacks catalytic activity. (J:166476)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbk1 Mutation: 54 strains or lines available

References

• Original: J:166476 Marchlik E, et al., Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality. J Leukoc Biol. 2010 Dec;88(6):1171-80
• All: 4 reference(s)