Tbk1^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Tbk1^tm1Lex
• Name: TANK-binding kinase 1; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:4847639
• Synonyms: Tbk1^cko
• Gene: Tbk1 Location: Chr10:121382360-121422692 bp, - strand Genetic Position: Chr10, 69.84 cM
• Alliance: Tbk1^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166476
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and a neo with 3' loxP site was inserted downstream of exon 2. (J:166476)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tbk1 Mutation: 54 strains or lines available

References

• Original: J:166476 Marchlik E, et al., Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality. J Leukoc Biol. 2010 Dec;88(6):1171-80
• All: 6 reference(s)