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Targeted Allele Detail
Symbol: Ep400tm3Fuku
Name: E1A binding protein p400; targeted mutation 3, Rikiro Fukunaga
MGI ID: MGI:4845874
Synonyms: mDomfl
Gene: Ep400  Location: Chr5:110812239-110918583 bp, - strand  Genetic Position: Chr5, 53.69 cM, cytoband F
Loss of bone marrow hematopoietic cells in Ep400tm3Fuku/Ep400tm3.1Fuku Tg(Mx1-cre)1Cgn/0 mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:166397
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 15, and an FRT and loxP flanked neo cassette was inserted downstream of exon 15. Flp-mediated recombination removed the neo cassette leaving exon 15 floxed. (J:166397)
Generation of the Ep400tm3Fuku and Ep400tm3.1Fuku alleles
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ep400 Mutation:  99 strains or lines available
Original:  J:166397 Fujii T, et al., Essential role of p400/mDomino chromatin-remodeling ATPase in bone marrow hematopoiesis and cell-cycle progression. J Biol Chem. 2010 Sep 24;285(39):30214-23
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory