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Ep400tm3Fuku
Targeted Allele Detail
Nomenclature
Symbol: Ep400tm3Fuku
Name: E1A binding protein p400; targeted mutation 3, Rikiro Fukunaga
MGI ID: MGI:4845874
Synonyms: mDomfl
Gene: Ep400  Location: Chr5:110812239-110918583 bp, - strand  Genetic Position: Chr5, 53.69 cM, cytoband F
Loss of bone marrow hematopoietic cells in Ep400tm3Fuku/Ep400tm3.1Fuku Tg(Mx1-cre)1Cgn/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:166397
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 15, and an FRT and loxP flanked neo cassette was inserted downstream of exon 15. Flp-mediated recombination removed the neo cassette leaving exon 15 floxed. (J:166397)
Generation of the Ep400tm3Fuku and Ep400tm3.1Fuku alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ep400 Mutation:  99 strains or lines available
References
Original:  J:166397 Fujii T, et al., Essential role of p400/mDomino chromatin-remodeling ATPase in bone marrow hematopoiesis and cell-cycle progression. J Biol Chem. 2010 Sep 24;285(39):30214-23
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/26/2022
MGI 6.21
The Jackson Laboratory