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Pik3catm1.1Rzl
Targeted Allele Detail
Nomenclature
Symbol: Pik3catm1.1Rzl
Name: phosphatidylinositol 3-kinase, catalytic, alpha polypeptide; targeted mutation 1.1, Richard Z Lin
MGI ID: MGI:4845856
Synonyms: p110alphaFlox, pik3ca1 loxP
Gene: Pik3ca  Location: Chr3:32397671-32466107 bp, + strand  Genetic Position: Chr3, 15.7 cM, cytoband B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:166421
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 1, and an FRT and loxP flanked neo cassette was inserted downstream of exon 2. Flp-mediated recombination removed the neo cassette leaving exon 1 floxed. (J:166421)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pik3ca Mutation:  14 strains or lines available
References
Original:  J:166421 Lu Z, et al., Loss of cardiac phosphoinositide 3-kinase p110 alpha results in contractile dysfunction. Circulation. 2009 Jul 28;120(4):318-25
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory