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Symbol: |
Ppp2r1atm1a(KOMP)Mbp |
Name: |
protein phosphatase 2, regulatory subunit A, alpha; targeted mutation 1a, Mouse Biology Program, UC Davis |
MGI ID: |
MGI:4843580 |
Gene: |
Ppp2r1a Location: Chr17:21165716-21186167 bp, + strand Genetic Position: Chr17, 11.4 cM, cytoband A3.2
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IMPC: |
Ppp2r1a gene page |
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Mutant Cell Lines: |
DEPD0003_15_A03, DEPD0003_15_A07, DEPD0003_15_A12, DEPD0003_15_B02, DEPD0003_15_B05, DEPD0003_15_B07, DEPD0003_15_B12, DEPD0003_15_C06, DEPD0003_15_C07, DEPD0003_15_C08, DEPD0003_15_C11, DEPD0003_15_D05, DEPD0003_15_D06, DEPD0003_15_D09, DEPD0003_15_E06, DEPD0003_15_E07, DEPD0003_15_E08, DEPD0003_15_E09, DEPD0003_15_F07, DEPD0003_15_F08, DEPD0003_15_F12, DEPD0003_15_G03, DEPD0003_15_G05, DEPD0003_15_G12, DEPD0003_15_H01, DEPD0003_15_H04, DEPD0003_15_H12 |
Germline Transmission: |
Unknown
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Parent Cell Line: |
JM8A1.N3 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Project Collection: |
KOMP-CSD
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Allele Type: |
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Targeted (Conditional ready, Null/knockout, Reporter) |
Mutation: |
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Insertion
Vector: L1L2_Pgk_P
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Mutation details: The L1L2_Pgk_P cassette was inserted at position 21174452 of Chromosome 17 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the PGK promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 21175255. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:157064)
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Original: |
J:157064 University of California, Davis, Alleles produced for the KOMP project by the University of California, Davis. MGI Direct Data Submission. 2010; |
All: |
1 reference(s) |
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