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Targeted Allele Detail
Symbol: Pld3tm1e(EUCOMM)Wtsi
Name: phospholipase D family, member 3; targeted mutation 1e, Wellcome Trust Sanger Institute
MGI ID: MGI:4842606
Gene: Pld3  Location: Chr7:27532000-27553218 bp, - strand  Genetic Position: Chr7, 15.92 cM
Mutant Cell Lines:  EPD0636_1_A09, EPD0636_1_A10, EPD0636_1_A11, EPD0636_1_B11, EPD0636_1_B12, EPD0636_1_D09, EPD0636_1_D10, EPD0636_1_D11, EPD0636_1_D12, EPD0636_1_E09, EPD0636_1_F09, EPD0636_1_F10, EPD0636_1_F11, EPD0636_1_F12, EPD0636_1_G09, EPD0636_1_G10, EPD0636_1_G11, EPD0636_1_G12, EPD0636_1_H09, EPD0636_1_H10, EPD0636_1_H12
Germline Transmission:  Earliest citation of germline transmission: J:204812
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_Bact_P
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 27538202 of Chromosome 7 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Insertion of this cassette creates a reporter knockout mouse. Cre expression will remove the neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:173534)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 1 line available
Carrying any Pld3 Mutation:  64 strains or lines available
Original:  J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory