Ezr^{tm4a(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Ezr^{tm4a(EUCOMM)Wtsi}
• Name: ezrin; targeted mutation 4a, Wellcome Trust Sanger Institute
• MGI ID: MGI:4842286
• Gene: Ezr Location: Chr17:7005530-7050179 bp, - strand Genetic Position: Chr17, 4.38 cM
• IMPC: Ezr gene page

Mutation origin

• Mutant Cell Lines: EPD0677_3_A03, EPD0677_3_A04, EPD0677_3_A05, EPD0677_3_A07, EPD0677_3_A08, EPD0677_3_A09, EPD0677_3_A10, EPD0677_3_A11, EPD0677_3_A12, EPD0677_3_B01, EPD0677_3_B04, EPD0677_3_B05, EPD0677_3_B06, EPD0677_3_B07, EPD0677_3_B08, EPD0677_3_B09, EPD0677_3_B10, EPD0677_3_B11, EPD0677_3_B12, EPD0677_3_C01, EPD0677_3_C02, EPD0677_3_C03, EPD0677_3_C05, EPD0677_3_C06, EPD0677_3_C08, EPD0677_3_C09, EPD0677_3_C10, EPD0677_3_C12, EPD0677_3_D01, EPD0677_3_D05, EPD0677_3_D06, EPD0677_3_D07, EPD0677_3_D08, EPD0677_3_D09, EPD0677_3_D10, EPD0677_3_D11, EPD0677_3_D12, EPD0677_3_E01, EPD0677_3_E03, EPD0677_3_E04, EPD0677_3_E05, EPD0677_3_E06, EPD0677_3_E07, EPD0677_3_E08, EPD0677_3_E09, EPD0677_3_E11, EPD0677_3_E12, EPD0677_3_F01, EPD0677_3_F02, EPD0677_3_F03, EPD0677_3_F04, EPD0677_3_F05, EPD0677_3_F06, EPD0677_3_F07, EPD0677_3_F08, EPD0677_3_F09, EPD0677_3_F10, EPD0677_3_F11, EPD0677_3_F12, EPD0677_3_G01, EPD0677_3_G02, EPD0677_3_G03, EPD0677_3_G05, EPD0677_3_G06, EPD0677_3_G08, EPD0677_3_G09, EPD0677_3_G11, EPD0677_3_G12, EPD0677_3_H01, EPD0677_3_H02, EPD0677_3_H04, EPD0677_3_H06, EPD0677_3_H08, EPD0677_3_H09, EPD0677_3_H10, EPD0677_3_H11, EPD0677_3_H12
• Germline Transmission: Unknown
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout, Reporter)
• Mutation: Insertion Vector: L1L2_gt2
• Mutation details: The L1L2_gt2 cassette was inserted at position 7014422 of Chromosome 17 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 7015180. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:173534)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ezr Mutation: 80 strains or lines available

References

• Original: J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010
• All: 2 reference(s)