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Cars2m1Btlr
Chemically induced Allele Detail
Summary
Symbol: Cars2m1Btlr
Name: cysteinyl-tRNA synthetase 2, mitochondrial; mutation 1, Bruce Beutler
MGI ID: MGI:4840539
Synonyms: madcow
Gene: Cars2  Location: Chr8:11564017-11600781 bp, - strand  Genetic Position: Chr8, 5.73 cM, cytoband A2
Alliance: Cars2m1Btlr page
Mutation
origin
Strain of Origin:  C57BL/6J
Project Collection: Beutler Mutagenetix
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsThis mutation, in the ninth of the gene's 15 exons, corresponds to a T to A transversion at nucleotide position 1007 of the transcript (GenBank Accession NM_024248). It is predicted to result in replacement of serine by threonine at amino acid position 305 of the protein (S305T), in the conserved KMSKS motif. (J:167594)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cars2 Mutation:  30 strains or lines available
References
Original:  J:167594 Eidenschenk C, et al., Madcow, a mutation in the mitochondrial cysteinyl-tRNA synthetase gene, results in an age-related neurobehavioral phenotype. MGI Direct Data Submission. 2011;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory