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Sh2d1b1/Sh2d1b2tm1.1Cpt
Targeted Allele Detail
Nomenclature
Symbol: Sh2d1b1/Sh2d1b2tm1.1Cpt
Name: SH2 domain containing 1B1; targeted mutation 1.1, Cox Terhorst
MGI ID: MGI:4840395
Synonyms: EAT-2A/B-
Gene: Sh2d1b1  Location: Chr1:170277320-170286769 bp, + strand  Genetic Position: Chr1, 76.84 cM, cytoband H2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:166054
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsExon 1 of Sh2d1b1 was replaced with a floxed neo cassette while exon 1 of Sh2d1b2 was replaced with a hygro cassette with a 5' loxP site. Cre mediated recombination removed the intervening sequence. (J:166054)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sh2d1b1 Mutation:  1 strain or line available
References
Original:  J:166054 Wang N, et al., Cutting edge: The adapters EAT-2A and -2B are positive regulators of CD244- and CD84-dependent NK cell functions in the C57BL/6 mouse. J Immunol. 2010 Nov 15;185(10):5683-7
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory