Tg(Gata4*G4-lacZ)1Blk
Transgene Detail

Summary

• Symbol: Tg(Gata4*G4-lacZ)1Blk
• Name: transgene insertion 1, Brian L Black
• MGI ID: MGI:4840266
• Synonyms: Gata4-G4-lacZ
• Transgene: Tg(Gata4*G4-lacZ)1Blk Location: unknown
• Alliance: Tg(Gata4*G4-lacZ)1Blk page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: The 1107 bp intronic G4 endodermal enhancer sequence (GenBank Acc ID HM212783) was cloned in front of an Hsp68-lacZ reporter sequence in a reporter plasmid. The construct was digested from the plasmid backbone, purified, and used for pronuclear injection. Seven founders were generated. Six showed consisted lacZ expression patterns during embryonic development. (J:165741)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:165741 Rojas A, et al., Direct transcriptional regulation of Gata4 during early endoderm specification is controlled by FoxA2 binding to an intronic enhancer. Dev Biol. 2010 Oct 15;346(2):346-55
• All: 1 reference(s)