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Targeted Allele Detail
Symbol: Cthtm1Iish
Name: cystathionase (cystathionine gamma-lyase); targeted mutation 1, Isao Ishii
MGI ID: MGI:4840236
Synonyms: CSE-KO
Gene: Cth  Location: Chr3:157894248-157925077 bp, - strand  Genetic Position: Chr3, 81.55 cM
Proximal muscle atrophy in Cthtm1Iish/Cthtm1Iish mice fed a low cysteine diet

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:166184
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 1 through 4 were replaced with a lacZ and neo cassette. The absence of protein expression was confirmed by western blot analysis on liver and kidney extract. (J:166184)
Generation of the Cthtm1Iish allele
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cth Mutation:  20 strains or lines available
Original:  J:166184 Ishii I, et al., Cystathionine gamma-Lyase-deficient mice require dietary cysteine to protect against acute lethal myopathy and oxidative injury. J Biol Chem. 2010 Aug 20;285(34):26358-68
All:  7 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory