Cth^tm1Iish
Targeted Allele Detail

Summary

• Symbol: Cth^tm1Iish
• Name: cystathionine gamma lyase; targeted mutation 1, Isao Ishii
• MGI ID: MGI:4840236
• Synonyms: CSE-KO
• Gene: Cth Location: Chr3:157599885-157630714 bp, - strand Genetic Position: Chr3, 81.55 cM
• Alliance: Cth^tm1Iish page

Proximal muscle atrophy in Cth^tm1Iish/Cth^tm1Iish mice fed a low cysteine diet

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166184
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: Exons 1 through 4 were replaced with a lacZ and neo cassette. The absence of protein expression was confirmed by western blot analysis on liver and kidney extract. (J:166184)

Generation of the Cth^tm1Iish allele

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cth Mutation: 32 strains or lines available

References

• Original: J:166184 Ishii I, et al., Cystathionine gamma-Lyase-deficient mice require dietary cysteine to protect against acute lethal myopathy and oxidative injury. J Biol Chem. 2010 Aug 20;285(34):26358-68
• All: 17 reference(s)