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Vcantm1.1Hwat
Targeted Allele Detail
Nomenclature
Symbol: Vcantm1.1Hwat
Name: versican; targeted mutation 1.1, Hideto Watanabe
MGI ID: MGI:4840040
Synonyms: Vcanflox
Gene: Vcan  Location: Chr13:89655312-89742509 bp, - strand  Genetic Position: Chr13, 45.5 cM
Limb deformities in Vcantm1.1Hwat/Vcantm1.1Hwat Tg(Prrx1-cre)1Cjt/0 mice

Show the 5 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:165936
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 2 and an FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neo cassette leaving exon 2 floxed. (J:165936)
Generation of the Vcantm1.1Hwat allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vcan Mutation:  9 strains or lines available
References
Original:  J:165936 Choocheep K, et al., Versican facilitates chondrocyte differentiation and regulates joint morphogenesis. J Biol Chem. 2010 Jul 2;285(27):21114-25
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory