P2ry13^tm1Loma
Targeted Allele Detail

Summary

• Symbol: P2ry13^tm1Loma
• Name: purinergic receptor P2Y, G-protein coupled 13; targeted mutation 1, Laurent O Martinez
• MGI ID: MGI:4839758
• Gene: P2ry13 Location: Chr3:59115313-59118303 bp, - strand Genetic Position: Chr3, 29.01 cM, cytoband D
• Alliance: P2ry13^tm1Loma page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166205
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first non-coding exon and 182 bp of the second codon were replaced with a neo cassette. The absence of full-length transcript expression was confirmed by RT-PCR on liver extracts. (J:166205)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any P2ry13 Mutation: 20 strains or lines available

References

• Original: J:166205 Fabre AC, et al., P2Y13 receptor is critical for reverse cholesterol transport. Hepatology. 2010 Oct;52(4):1477-83
• All: 8 reference(s)