Adrb1^tm1.1Rjl
Targeted Allele Detail

Summary

• Symbol: Adrb1^tm1.1Rjl
• Name: adrenergic receptor, beta 1; targeted mutation 1.1, Robert J Lefkowitz
• MGI ID: MGI:4839639
• Gene: Adrb1 Location: Chr19:56710549-56713582 bp, + strand Genetic Position: Chr19, 51.96 cM
• Alliance: Adrb1^tm1.1Rjl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166049
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The final serine residue (the third from the end) was mutated to alanine to prohibit PDZ protein (post synaptic density protein (PSD95, Dlg4), Drosophila disc large tumor suppressor (DlgA; Dlg1), and zonula occludens-1 protein (zo-1; Tjp1)) binding. A residual loxP site is located in the 3' UTR after excision of a loxP-flanked neomycin cassette. (J:166049)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adrb1 Mutation: 19 strains or lines available

References

• Original: J:166049 Lefkowitz RJ, Direct submission 2010/11/29_XTglr4. MGI Direct Data Submission. 2010
• All: 1 reference(s)