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Targeted Allele Detail
Symbol: Med12tm1.2Hsch
Name: mediator complex subunit 12; targeted mutation 1.2, Heinrich Schrewe
MGI ID: MGI:4839486
Synonyms: Med12delta1-7
Gene: Med12  Location: ChrX:101274030-101297465 bp, + strand  Genetic Position: ChrX, 43.91 cM, cytoband C2
Mouse Generated:  Earliest citation of chimera generation: J:166040
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsOne loxP site was inserted in the 5'UTR of exon 1 while a second loxP site, followed by an FRT flanked neomycin cassette in reverse orientation, was inserted in intron 7. The selection cassette was subsequently removed by transient flp recombinase expression leaving exons 1-7 flanked by loxP sites. Transient cre expression then excised the floxed exons. (J:166040)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Med12 Mutation:  7 strains or lines available
Original:  J:166040 Rocha PP, et al., Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling. Development. 2010 Aug;137(16):2723-31
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory