Has2^tm1.2Nita
Targeted Allele Detail

Summary

• Symbol: Has2^tm1.2Nita
• Name: hyaluronan synthase 2; targeted mutation 1.2, Naoki Itano
• MGI ID: MGI:4839366
• Gene: Has2 Location: Chr15:56529023-56557935 bp, - strand Genetic Position: Chr15, 23.31 cM
• Alliance: Has2^tm1.2Nita page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164205
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was floxed and a FRT flanked neomycin cassette was inserted within intron 2 by homologous recombination. The selection cassette and exon 2 were removed by flpe and cre mediated recombination respectivly. (J:164205)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Has2 Mutation: 35 strains or lines available

References

• Original: J:164205 Kobayashi N, et al., Hyaluronan deficiency in tumor stroma impairs macrophage trafficking and tumor neovascularization. Cancer Res. 2010 Sep 15;70(18):7073-83
• All: 1 reference(s)