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Has2tm1.2Nita
Targeted Allele Detail
Nomenclature
Symbol: Has2tm1.2Nita
Name: hyaluronan synthase 2; targeted mutation 1.2, Naoki Itano
MGI ID: MGI:4839366
Gene: Has2  Location: Chr15:56665627-56694539 bp, - strand  Genetic Position: Chr15, 23.31 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:164205
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 was floxed and a FRT flanked neomycin cassette was inserted within intron 2 by homologous recombination. The selection cassette and exon 2 were removed by flpe and cre mediated recombination respectivly. (J:164205)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Has2 Mutation:  14 strains or lines available
References
Original:  J:164205 Kobayashi N, et al., Hyaluronan deficiency in tumor stroma impairs macrophage trafficking and tumor neovascularization. Cancer Res. 2010 Sep 15;70(18):7073-83
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/11/2017
MGI 6.10
The Jackson Laboratory