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Adam10tm2Psa
Targeted Allele Detail
Nomenclature
Symbol: Adam10tm2Psa
Name: a disintegrin and metallopeptidase domain 10; targeted mutation 2, Paul Saftig
MGI ID: MGI:4838238
Synonyms: Adam10Fl
Gene: Adam10  Location: Chr9:70678997-70780229 bp, + strand  Genetic Position: Chr9, 39.53 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:159624
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe hygromycin B resistance gene, driven by the PGK (phosphoglycerate kinase) promoter flanked with two flippase recognition target sequences, one loxP sequence downstream of the hygromycin B resistance gene, was inserted in 5' upstream of exon2 in intron1. A second loxP sequence was inserted in intron 2. This is a conditional allele. (J:159624)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adam10 Mutation:  5 strains or lines available
References
Original:  J:159624 Jorissen E, et al., The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex. J Neurosci. 2010 Apr 7;30(14):4833-44
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory