Tg(TTR-INSR)#Dac
Transgene Detail

Summary

• Symbol: Tg(TTR-INSR)#Dac
• Name: transgene insertion, Domenico Accili
• MGI ID: MGI:4838213
• Transgene: Tg(TTR-INSR)#Dac Location: unknown
• Alliance: Tg(TTR-INSR)#Dac page

Transgene origin

• Strain of Origin: C57BL/6 x FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(TTR-INSR)#Dac expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  INSR (3643)

  Insr	(MGI:96575)

• Mutation details: A human insulin receptor cDNA was inserted in exon 3 of a 3kbp human TTR fragment containin the promoter and exons 1-3. The insulin receptor cDNA is thus placed under the control of the human TTR promoter. Three founder lines were established (L1, L2, L3). Highest expression was found in L1 for which the insertion copy number is 20. The pound symbol (#) denotes when no line number is specified. (J:91350)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:164772 Symons JD, et al., Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure. Circ Res. 2009 May 8;104(9):1085-94
• All: 4 reference(s)