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Cacna1btm2.1Dili
Targeted Allele Detail
Nomenclature
Symbol: Cacna1btm2.1Dili
Name: calcium channel, voltage-dependent, N type, alpha 1B subunit; targeted mutation 2.1, Diane Lipscombe
MGI ID: MGI:4838019
Synonyms: Cacna1bb*b
Gene: Cacna1b  Location: Chr2:24603887-24763152 bp, - strand  Genetic Position: Chr2, 16.58 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:165258
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted
Mutation:    Intragenic deletion
 
Mutation detailsUsing MICER clone MHPN59f07, exon 37a was replaced with a modified exon 37b, which lacked the XhoI restriction site, and a floxed neo cassette. Cre mediated recombination removed the neo cassette. (J:165258)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cacna1b Mutation:  5 strains or lines available
References
Original:  J:165258 Andrade A, et al., Opioid inhibition of N-type Ca2+ channels and spinal analgesia couple to alternative splicing. Nat Neurosci. 2010 Oct;13(10):1249-56
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/04/2020
MGI 6.14
The Jackson Laboratory