Fadd^tm2Wnt
Targeted Allele Detail

Summary

• Symbol: Fadd^tm2Wnt
• Name: Fas associated via death domain; targeted mutation 2, Astar Winoto
• MGI ID: MGI:4837701
• Synonyms: FADD^floxneo
• Gene: Fadd Location: Chr7:144132060-144136178 bp, - strand Genetic Position: Chr7, 88.85 cM
• Alliance: Fadd^tm2Wnt page

Mutation origin

• Mouse Generated: Earliest citation of chimera generation: J:162312
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The knockout construct contains a loxP flanked neomycin resistance cassette inserted between exons 1 and 2 of FADD, and an additional loxP site upstream of exon 1. (J:162312)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fadd Mutation: 19 strains or lines available

References

• Original: J:162312 Osborn SL, et al., Fas-associated death domain (FADD) is a negative regulator of T-cell receptor-mediated necroptosis. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13034-9
• All: 1 reference(s)