Maf1^tm1.1Lnh
Targeted Allele Detail

Summary

• Symbol: Maf1^tm1.1Lnh
• Name: MAF1 homolog, negative regulator of RNA polymerase III; targeted mutation 1.1, Nouria Hernandez
• MGI ID: MGI:4837337
• Gene: Maf1 Location: Chr15:76235494-76238578 bp, + strand Genetic Position: Chr15, 35.75 cM, cytoband E1
• Alliance: Maf1^tm1.1Lnh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162787
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The targeting vector is designed to insert one loxP site in intron 2 (481 bp 5' of the start codon), an FRT-flanked neomycin resistance (neo) cassette in exon 8, followed by a loxP site (221 bp 3' of the stop codon). Cre-mediated recombination removed the targeted sequence. (J:222253)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Maf1 Mutation: 11 strains or lines available

References

• Original: J:162787 Michels AA, et al., mTORC1 directly phosphorylates and regulates human MAF1. Mol Cell Biol. 2010 Aug;30(15):3749-57
• All: 4 reference(s)