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Targeted Allele Detail
Symbol: Mdm2tm1.1Ypz
Name: transformed mouse 3T3 cell double minute 2; targeted mutation 1.1, Yangping Zhang
MGI ID: MGI:4836988
Synonyms: Mdm2C305F
Gene: Mdm2  Location: Chr10:117688888-117710758 bp, - strand  Genetic Position: Chr10, 66.32 cM, cytoband C1-C3
Germline Transmission:  Earliest citation of germline transmission: J:164200
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsSite-directed mutagenesis converted the TGT codon to TTT resulting in the amino acid substitution of phenylalanine for cysteine at position 305 (C305F). Additional codons were modified to introduce an SpeI site. A floxed neo cassette was removed by cre mediated recombination. The amino acid substitution disrupts binding to Smr3a (RPL5) and RPL11. (J:164200)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mdm2 Mutation:  31 strains or lines available
Original:  J:164200 Macias E, et al., An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction. Cancer Cell. 2010 Sep 14;18(3):231-43
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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