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Arid1atm1.1Gusa
Targeted Allele Detail
Nomenclature
Symbol: Arid1atm1.1Gusa
Name: AT rich interactive domain 1A (SWI-like); targeted mutation 1.1, Guy Sauvageau
MGI ID: MGI:4836625
Synonyms: BAF250aE2E3
Gene: Arid1a  Location: Chr4:133679008-133756769 bp, - strand  Genetic Position: Chr4, 66.25 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:164526
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 2 and a floxed neo cassette was inserted downstream of exon 3. Cre mediated recombination removed exon 2, exon 3, and the neo cassette. The expression of a truncated protein was confirmed by western blot analysis on embryonic fibroblasts. The truncated protein lacks 150 amino acids of the N-terminus without affecting expression levels or protein interaction with Smarca4 (Brg1). (J:164526)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arid1a Mutation:  161 strains or lines available
References
Original:  J:164526 Krosl J, et al., A mutant allele of the Swi/Snf member BAF250a determines the pool size of fetal liver hemopoietic stem cell populations. Blood. 2010 Sep 9;116(10):1678-84
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory