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Pla2g10tm1Itl
Targeted Allele Detail
Nomenclature
Symbol: Pla2g10tm1Itl
Name: phospholipase A2, group X; targeted mutation 1, inGenious Targeting Laboratory
MGI ID: MGI:4836546
Synonyms: GX sPLA2-, Pla2g10tm1Igl
Gene: Pla2g10  Location: Chr16:13715057-13730983 bp, - strand  Genetic Position: Chr16, 9.5 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:164545
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neo cassette replaced 564 bp of exon 1. The absence of protein expression was confirmed by immunohistochemistry on adrenal glands. (J:164545)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pla2g10 Mutation:  33 strains or lines available
References
Original:  J:164545 Shridas P, et al., Group X secretory phospholipase A2 regulates the expression of steroidogenic acute regulatory protein (StAR) in mouse adrenal glands. J Biol Chem. 2010 Jun 25;285(26):20031-9
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory