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Targeted Allele Detail
Symbol: Cyp51tm1.1Bfro
Name: cytochrome P450, family 51; targeted mutation 1.1, Simon Horvat
MGI ID: MGI:4836362
Gene: Cyp51  Location: Chr5:4081145-4104746 bp, - strand  Genetic Position: Chr5, 2.3 cM, cytoband A2
Morphological developmental abnormalities in Cyp51tm1.1Bfro/Cyp51tm1.1Bfro embryos

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:173366
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsExons 3 and 4 were excised by crossing Cyp51 mice to Tg(EIIa-cre)C5379Lmgd mice. Absence of gene expression was confirmed by quantitative RT-PCR. No immunologically detectable protein was observed on Western blots. (J:173366)
Generation of the Cyp51tm1Bfro and Cyp51tm1.1Bfro alleles
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cyp51 Mutation:  9 strains or lines available
Original:  J:173366 Keber R, et al., Mouse knockout of the cholesterogenic cytochrome P450 lanosterol 14{alpha}-Demethylase (CYP51) resembles Antley-Bixler syndrome. J Biol Chem. 2011 Jun 25;
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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