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Cyp51tm1.1Bfro
Targeted Allele Detail
Summary
Symbol: Cyp51tm1.1Bfro
Name: cytochrome P450, family 51; targeted mutation 1.1, Simon Horvat
MGI ID: MGI:4836362
Gene: Cyp51  Location: Chr5:4131145-4154746 bp, - strand  Genetic Position: Chr5, 2.3 cM, cytoband A2
Alliance: Cyp51tm1.1Bfro page
Morphological developmental abnormalities in Cyp51tm1.1Bfro/Cyp51tm1.1Bfro embryos

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:173366
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprt1b-m3
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExons 3 and 4 were excised by crossing Cyp51 mice to Tg(EIIa-cre)C5379Lmgd mice. Absence of gene expression was confirmed by quantitative RT-PCR. No immunologically detectable protein was observed on Western blots. (J:173366)
Generation of the Cyp51tm1Bfro and Cyp51tm1.1Bfro alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 22 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cyp51 Mutation:  24 strains or lines available
References
Original:  J:173366 Keber R, et al., Mouse knockout of the cholesterogenic cytochrome P450 lanosterol 14alpha-demethylase (Cyp51) resembles Antley-Bixler syndrome. J Biol Chem. 2011 Aug 19;286(33):29086-97
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory