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Cyp51tm1.1Bfro
Targeted Allele Detail
Nomenclature
Symbol: Cyp51tm1.1Bfro
Name: cytochrome P450, family 51; targeted mutation 1.1, Simon Horvat
MGI ID: MGI:4836362
Gene: Cyp51  Location: Chr5:4081145-4104746 bp, - strand  Genetic Position: Chr5, 2.3 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:173366
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExons 3 and 4 were excised by crossing Cyp51 mice to Tg(EIIa-cre)C5379Lmgd mice. Absence of gene expression was confirmed by quantitative RT-PCR. No immunologically detectable protein was observed on Western blots. (J:173366)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cyp51 Mutation:  8 strains or lines available
References
Original:  J:173366 Keber R, et al., Mouse knockout of the cholesterogenic cytochrome P450 lanosterol 14{alpha}-Demethylase (CYP51) resembles Antley-Bixler syndrome. J Biol Chem. 2011 Jun 25;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory