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Prkaa1tm1.1Sjm
Targeted Allele Detail
Nomenclature
Symbol: Prkaa1tm1.1Sjm
Name: protein kinase, AMP-activated, alpha 1 catalytic subunit; targeted mutation 1.1, Sean J Morrison
MGI ID: MGI:4836199
Synonyms: AMPKa1fl, Prkaa1fl
Gene: Prkaa1  Location: Chr15:5173343-5211380 bp, + strand  Genetic Position: Chr15, 1.99 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:165090
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 3 and an FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neo selection cassette. (J:165090)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prkaa1 Mutation:  35 strains or lines available
References
Original:  J:165090 Nakada D, et al., Lkb1 regulates cell cycle and energy metabolism in hematopoietic stem cells. Nature. 2010;468(7324):653-658
All:  47 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory