Tg(Ins2-BCL2L1)1Dh
Transgene Detail

Summary

• Symbol: Tg(Ins2-BCL2L1)1Dh
• Name: transgene insertion 1, Douglas Hanahan
• MGI ID: MGI:4836173
• Transgene: Tg(Ins2-BCL2L1)1Dh Location: unknown
• Alliance: Tg(Ins2-BCL2L1)1Dh page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ins2-BCL2L1)1Dh expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BCL2L1 (598)

  Bcl2l1

  (MGI:88139)

• Tg(Ins2-BCL2L1)1Dh expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Ins2 (24506)

  Ins2	(MGI:96573)

• Mutation details: A0.8 kb fragment of human BCL2L1 was placed under the control of a 9.5 kb 5' regulatory region of the rat insulin II gene. Two independent founder lines were obtained, both with expression levels 20 fold greater thean the endogenous gene. Line 1 was used in further crosses. (J:76998)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:76998 Naik P, et al., The rise and fall of apoptosis during multistage tumorigenesis: down-modulation contributes to tumor progression from angiogenic progenitors. Genes Dev. 1996 Sep 1;10(17):2105-16
• All: 1 reference(s)