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Targeted Allele Detail
Symbol: Plp1tm1Gow
Name: proteolipid protein (myelin) 1; targeted mutation 1, Alexander Gow
MGI ID: MGI:4835262
Synonyms: Plp neo
Gene: Plp1  Location: ChrX:136822671-136839733 bp, + strand  Genetic Position: ChrX, 59.1 cM, cytoband F1-F2
Germline Transmission:  Earliest citation of germline transmission: J:62287
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsThe splice donor site at the 3' end of exon 3 was inactivated by site directed mutagenesis. A floxed PGKneo selection cassette was then inserted at position 49 of intron 3. Presence of the floxed neo prevents protein expression. (J:62287)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plp1 Mutation:  16 strains or lines available
Original:  J:62287 Stecca B, et al., The evolution of lipophilin genes from invertebrates to tetrapods: DM-20 cannot replace proteolipid protein in CNS myelin. J Neurosci. 2000 Jun 1;20(11):4002-10
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory