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Targeted Allele Detail
Symbol: Serpina6tm1.1Mmp
Name: serine (or cysteine) peptidase inhibitor, clade A, member 6; targeted mutation 1.1, Marie-Pierre Moisan
MGI ID: MGI:4833641
Synonyms: Cbg-, Cbg knockout, transcortin knockout
Gene: Serpina6  Location: Chr12:103646630-103657212 bp, - strand  Genetic Position: Chr12, 52.98 cM
Germline Transmission:  Earliest citation of germline transmission: J:164345
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe loxP-flanked exon 2 of Serpina6tm1Mmp, containing the entire protein coding sequence, has been excised by Cre recombinase. Quantitative real-time PCR analysis of liver mRNA detects no transcripts from the targeted gene in homozygous mutant mice and ~50% of wild-type transcript levels in heterozygous mice. Immunoblot analysis of plasma of homozygous mutant, heterozygous and wild-type mice yields confirmatory results for the for the protein. (J:164345)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Serpina6 Mutation:  19 strains or lines available
Gene targeting to generate Serpina6tm1Mmp was performed at the Mouse Clinical Institute (Illkirch, France)(J:164345), which according to their Web site (http://www.ics-mci.fr/index.html) employs "ES cells of the 129SvPas strain."
Original:  J:164345 Richard EM, et al., Plasma transcortin influences endocrine and behavioral stress responses in mice. Endocrinology. 2010 Feb;151(2):649-59
All:  2 reference(s)

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MGI 6.11
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