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Targeted Allele Detail
Symbol: Serpina6tm1.1Mmp
Name: serine (or cysteine) peptidase inhibitor, clade A, member 6; targeted mutation 1.1, Marie-Pierre Moisan
MGI ID: MGI:4833641
Synonyms: Cbg-, Cbg knockout, transcortin knockout
Gene: Serpina6  Location: Chr12:103646630-103657212 bp, - strand  Genetic Position: Chr12, 52.98 cM
Germline Transmission:  Earliest citation of germline transmission: J:164345
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe loxP-flanked exon 2 of Serpina6tm1Mmp, containing the entire protein coding sequence, has been excised by Cre recombinase. Quantitative real-time PCR analysis of liver mRNA detects no transcripts from the targeted gene in homozygous mutant mice and ~50% of wild-type transcript levels in heterozygous mice. Immunoblot analysis of plasma of homozygous mutant, heterozygous and wild-type mice yields confirmatory results for the for the protein. (J:164345)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Serpina6 Mutation:  19 strains or lines available
Gene targeting to generate Serpina6tm1Mmp was performed at the Mouse Clinical Institute (Illkirch, France)(J:164345), which according to their Web site (http://www.ics-mci.fr/index.html) employs "ES cells of the 129SvPas strain."
Original:  J:164345 Richard EM, et al., Plasma transcortin influences endocrine and behavioral stress responses in mice. Endocrinology. 2010 Feb;151(2):649-59
All:  2 reference(s)

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MGI 6.12
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