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Tnfaip3tm2Ama
Targeted Allele Detail
Nomenclature
Symbol: Tnfaip3tm2Ama
Name: tumor necrosis factor, alpha-induced protein 3; targeted mutation 2, Averil Ma
MGI ID: MGI:4831001
Synonyms: A20FL, Tnfaip3fl
Gene: Tnfaip3  Location: Chr10:19000910-19015410 bp, - strand  Genetic Position: Chr10, 8.08 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:163917
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe targeting construct contained exon 2 flanked by loxP sites along with a loxP flanked neomycin cassette.The neomycin cassette was removed by transient transfection of Cre recombinase. (J:163917)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfaip3 Mutation:  28 strains or lines available
References
Original:  J:163917 Tavares RM, et al., The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity. Immunity. 2010 Aug 27;33(2):181-91
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory