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Comttm1Mkae
Targeted Allele Detail
Nomenclature
Symbol: Comttm1Mkae
Name: catechol-O-methyltransferase; targeted mutation 1, Mikko Kaenmaki
MGI ID: MGI:4830700
Synonyms: S-COMT
Gene: Comt  Location: Chr16:18225636-18245602 bp, - strand  Genetic Position: Chr16, 11.4 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:164057
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Modified isoform(s))
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsA mutation of the methionine coding start codon (ATG) for S-COMT to threonine (ACC), corresponding to 'ATG' position +30 in exon2 of Comt gene and a floxed neo cassette in intron 4 were introduced by homologous recombination. The selection cassette was removed by cre mediated recombination. The S-COMT (24 kDa) isoform was absent on western blots of liver extracts, while the MB-COMT was detected. (J:164057)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Comt Mutation:  18 strains or lines available
Notes
ES cell line = 3B4
References
Original:  J:164057 Kaenmaki M, et al., Importance of membrane-bound catechol-O-methyltransferase in L-DOPA metabolism: a pharmacokinetic study in two types of Comt gene modified mice. Br J Pharmacol. 2009 Dec;158(8):1884-94
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory