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Slc47a1tm1Kinu
Targeted Allele Detail
Nomenclature
Symbol: Slc47a1tm1Kinu
Name: solute carrier family 47, member 1; targeted mutation 1, Ken-ichi Inui
MGI ID: MGI:4830581
Synonyms: Mate1-
Gene: Slc47a1  Location: Chr11:61234227-61269171 bp, - strand  Genetic Position: Chr11, 37.96 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:163959
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on brush-border membrane extracts. (J:163959)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc47a1 Mutation:  33 strains or lines available
References
Original:  J:163959 Tsuda M, et al., Targeted disruption of the multidrug and toxin extrusion 1 (mate1) gene in mice reduces renal secretion of metformin. Mol Pharmacol. 2009 Jun;75(6):1280-6
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory