About   Help   FAQ
P3h1tm1Dgen
Targeted Allele Detail
Nomenclature
Symbol: P3h1tm1Dgen
Name: prolyl 3-hydroxylase 1; targeted mutation 1, Deltagen
MGI ID: MGI:4830452
Gene: P3h1  Location: Chr4:119232915-119248975 bp, + strand  Genetic Position: Chr4, 55.34 cM, cytoband D1
Reduced body size and skeletal abnormalities in P3h1tm1Dgen/P3h1tm1Dgen mice

Show the 5 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:163884
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Project Collection: Deltagen
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 through 3 were replaced with a lacZ-neo cassette. The absences of transcript expression was confirmed by RT-PCR. (J:163884)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any P3h1 Mutation:  19 strains or lines available
References
Original:  J:163884 Vranka JA, et al., Prolyl 3-hydroxylase 1 null mice display abnormalities in fibrillar collagen-rich tissues such as tendons, skin, and bones. J Biol Chem. 2010 May 28;285(22):17253-62
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/16/2021
MGI 6.16
The Jackson Laboratory