Col2a1tm1.1Ksec
Targeted Allele Detail
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Symbol: |
Col2a1tm1.1Ksec |
Name: |
collagen, type II, alpha 1; targeted mutation 1.1, Kathryn S E Cheah |
MGI ID: |
MGI:4830258 |
Synonyms: |
IIA- |
Gene: |
Col2a1 Location: Chr15:97873483-97902525 bp, - strand Genetic Position: Chr15, 53.97 cM
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Alliance: |
Col2a1tm1.1Ksec page
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Germline Transmission: |
Earliest citation of germline transmission:
J:163739
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129X1/SvJ
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exon 2 was replaced with a floxed neo cassette via homologous recombination. Cre mediated recombination removed the neo cassette. RT-PCR analysis confirmed the absence of the IIA transcript and continued expression of the IIB transcript in E9.5 homozygous embryos. This is an isoform specific knock-out.
(J:163739)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Col2a1 Mutation: |
68 strains or lines available
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Original: |
J:163739 Leung AW, et al., Loss of procollagen IIA from the anterior mesendoderm disrupts the development of mouse embryonic forebrain. Dev Dyn. 2010 Sep;239(9):2319-29 |
All: |
2 reference(s) |
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