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Col2a1tm1.1Ksec
Targeted Allele Detail
Summary
Symbol: Col2a1tm1.1Ksec
Name: collagen, type II, alpha 1; targeted mutation 1.1, Kathryn S E Cheah
MGI ID: MGI:4830258
Synonyms: IIA-
Gene: Col2a1  Location: Chr15:97873483-97902525 bp, - strand  Genetic Position: Chr15, 53.97 cM
Alliance: Col2a1tm1.1Ksec page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:163739
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 was replaced with a floxed neo cassette via homologous recombination. Cre mediated recombination removed the neo cassette. RT-PCR analysis confirmed the absence of the IIA transcript and continued expression of the IIB transcript in E9.5 homozygous embryos. This is an isoform specific knock-out. (J:163739)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 96 assay results
In Structures Affected by this Mutation: 16 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col2a1 Mutation:  68 strains or lines available
References
Original:  J:163739 Leung AW, et al., Loss of procollagen IIA from the anterior mesendoderm disrupts the development of mouse embryonic forebrain. Dev Dyn. 2010 Sep;239(9):2319-29
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory