Foxp1^tm2.1Eem
Targeted Allele Detail

Summary

• Symbol: Foxp1^tm2.1Eem
• Name: forkhead box P1; targeted mutation 2.1, Edward E Morrisey
• MGI ID: MGI:4829787
• Synonyms: Foxp1^flox
• Gene: Foxp1 Location: Chr6:98902299-99499682 bp, - strand Genetic Position: Chr6, 45.74 cM, cytoband E1
• Alliance: Foxp1^tm2.1Eem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163662
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 10 and an FRT flanked neo cassette and second loxP site were inserted downstream of exon 13 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:163662)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxp1 Mutation: 75 strains or lines available

References

• Original: J:163662 Zhang Y, et al., Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanisms. Genes Dev. 2010 Aug 15;24(16):1746-57
• All: 4 reference(s)