Mir144/Mir451a^tm1.1Doca
Targeted Allele Detail

Summary

• Symbol: Mir144/Mir451a^tm1.1Doca
• Name: microRNA 451a; targeted mutation 1.1, Donal O'Carroll
• MGI ID: MGI:4829616
• Gene: Mir451a Location: Chr11:77963996-77964067 bp, + strand Genetic Position: Chr11, 46.74 cM
• Alliance: Mir144/Mir451a^tm1.1Doca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163418
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT flanked neo cassette with a 5' loxP site was inserted upstream of the transcription initiation site for both Mir144 and Mir451. An additional loxP site was inserted between the two microRNAs. Flp mediated recombination removed the neo cassette leaving the translation initiation site floxed. (J:163418)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir451a Mutation: 4 strains or lines available

References

• Original: J:163418 Rasmussen KD, et al., The miR-144/451 locus is required for erythroid homeostasis. J Exp Med. 2010 Jul 5;207(7):1351-8
• All: 1 reference(s)