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Targeted Allele Detail
Symbol: Cd300lbtm1Toki
Name: CD300 molecule like family member B; targeted mutation 1, Toshio Kitamura
MGI ID: MGI:4829592
Synonyms: LMIR5-
Gene: Cd300lb  Location: Chr11:114813605-114825197 bp, - strand  Genetic Position: Chr11, 80.55 cM
Cd300lbtm1Toki/Cd300lbtm1Toki mice were protected from renal ischemia reperfusion injury

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:163402
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA construct containing a lacZ cassette and an FRT flanked neo cassette that was flanked with a mutant lox71 site and a loxP site replaced part of exon 1 and intron 1 beginning at the initiation site. Flow cytometry analysis confirmed the absence of expression in bone marrow cells from homozygous mice. (J:163402)
Generation of the Cd300lbtm1Toki allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cd300lb Mutation:  20 strains or lines available
Original:  J:163402 Yamanishi Y, et al., TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury. J Exp Med. 2010 Jul 5;207(7):1501-11
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory