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Cd300lbtm1Toki
Targeted Allele Detail
Nomenclature
Symbol: Cd300lbtm1Toki
Name: CD300 molecule like family member B; targeted mutation 1, Toshio Kitamura
MGI ID: MGI:4829592
Synonyms: LMIR5-
Gene: Cd300lb  Location: Chr11:114813605-114825197 bp, - strand  Genetic Position: Chr11, 80.55 cM
Cd300lbtm1Toki/Cd300lbtm1Toki mice were protected from renal ischemia reperfusion injury

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:163402
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA construct containing a lacZ cassette and an FRT flanked neo cassette that was flanked with a mutant lox71 site and a loxP site replaced part of exon 1 and intron 1 beginning at the initiation site. Flow cytometry analysis confirmed the absence of expression in bone marrow cells from homozygous mice. (J:163402)
Generation of the Cd300lbtm1Toki allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cd300lb Mutation:  20 strains or lines available
References
Original:  J:163402 Yamanishi Y, et al., TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury. J Exp Med. 2010 Jul 5;207(7):1501-11
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/26/2022
MGI 6.21
The Jackson Laboratory