Itgax^{tm1(HBEGF)Ktak}
Targeted Allele Detail

Summary

• Symbol: Itgax^{tm1(HBEGF)Ktak}
• Name: integrin alpha X; targeted mutation 1, Kiyoshi Takeda
• MGI ID: MGI:4822467
• Synonyms: CD11c-iDTR
• Gene: Itgax Location: Chr7:127728719-127749829 bp, + strand Genetic Position: Chr7, 69.98 cM
• Alliance: Itgax^{tm1(HBEGF)Ktak} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162397
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Itgax^{tm1(HBEGF)Ktak} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  monkey	HBEGF

• Mutation details: A construct, which contained (5' to 3') a adenoviral splice acceptor, loxP site, double poly-adenylation sequence, FRT flanked neo cassette, STOP cassette, loxP site, simian diphtheria toxin receptor cDNA, and poly-adenylation sequence, was inserted downstream of exon 1. Cre mediated removal of the STOP cassette is required to achieve expression of the simian cDNA. (J:162397)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgax Mutation: 78 strains or lines available

References

• Original: J:162397 Okuyama M, et al., A novel in vivo inducible dendritic cell ablation model in mice. Biochem Biophys Res Commun. 2010 Jul 2;397(3):559-63
• All: 1 reference(s)