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Capn8tm1Hiso
Targeted Allele Detail
Nomenclature
Symbol: Capn8tm1Hiso
Name: calpain 8; targeted mutation 1, Hiroyuki Sorimachi
MGI ID: MGI:4822421
Gene: Capn8  Location: Chr1:182565007-182632352 bp, + strand  Genetic Position: Chr1, 85.37 cM, cytoband H4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:163312
Parent Cell Line:  RENKA (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 3 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on gastric mucosa. (J:163312)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Capn8 Mutation:  27 strains or lines available
References
Original:  J:163312 Hata S, et al., Calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense. PLoS Genet. 2010;6(7):e1001040
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory