Col4a1^D456
Radiation induced Allele Detail

Summary

• Symbol: Col4a1^D456
• Name: collagen, type IV, alpha 1; radiation induced mutation D456
• MGI ID: MGI:4822198
• Gene: Col4a1 Location: Chr8:11248423-11362826 bp, - strand Genetic Position: Chr8, 5.53 cM
• Alliance: Col4a1^D456 page

Mutation origin

• Strain of Origin: DBA/2

Mutation description

• Allele Type: Radiation induced
• Mutation: Single point mutation
• Mutation details: Male mice were exposed to two doses of 3 Gy of gamma radiation. This resulted in a G to A nucleotide replacement at position 2991 (NCBI accession # NM_009931) and a glycine to arginine substitution at amiono acid residue 954. (J:163225)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Col4a1 Mutation: 77 strains or lines available

References

• Original: J:163517 Favor J, et al., Radiation-induced forward and reverse specific locus mutations and dominant cataract mutations in treated strain BALB/c and DBA/2 male mice. Mutat Res. 1987 Mar;177(1):161-9
• All: 2 reference(s)