Tg(KRT18-cre/ERT2)23Blpn
Transgene Detail

Summary

• Symbol: Tg(KRT18-cre/ERT2)23Blpn
• Name: transgene insertion 23, Cedric Blanpain
• MGI ID: MGI:4821951
• Synonyms: K18-CREER
• Transgene: Tg(KRT18-cre/ERT2)23Blpn Location: unknown
• Alliance: Tg(KRT18-cre/ERT2)23Blpn page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(KRT18-cre/ERT2)23Blpn expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  KRT18 (3875)

  Krt18

  (MGI:96692)

• Mutation details: A fragment encoding cre recombinase fused to a modified estrogen receptor ligand-binding domain (ERT2) was cloned into a vector containing the human KRT18 promoter. The construct was injected into fertilized oocytes to generated transgenic mice. Two lines were obtained. Line 23 was used in the original reference. (J:163216)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	KRT18 (human) Summary of all recombinase alleles driven by KRT18. Alliance human KRT18 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:163216 Van Keymeulen A, et al., Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasis. J Cell Biol. 2009 Oct 5;187(1):91-100
• All: 7 reference(s)