Tg(Ins2-GH1)#Herr
Transgene Detail

Summary

• Symbol: Tg(Ins2-GH1)#Herr
• Name: transgene insertion, Pedro Luis Herrera
• MGI ID: MGI:4821343
• Synonyms: InsulinPr-loxP-STOP-loxP-hGH
• Transgene: Tg(Ins2-GH1)#Herr Location: unknown
• Alliance: Tg(Ins2-GH1)#Herr page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/J)F2

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Tg(Ins2-GH1)#Herr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  GH1 (2688)

  Gh	(MGI:95707)

• Tg(Ins2-GH1)#Herr expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Ins2 (24506)

  Ins2	(MGI:96573)

• Mutation details: The construct consisted of the rat insulin 2 promoter (Ins2; RIP), a loxP-STOP-loxP sequence and the human growth hormone gene (GH1; hGH). (C57BL/6J x CBA/J)F2 zygotes were injected and at least three founder lines were generated and a line with stable and complete transgene expression (i.e. in about 100% of targeted cells) was established. Crosses with cre-expressing animals will excise the STOP signal, resulting in GH1 expression as a tag. (J:78865)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:78865 Herrera PL, Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages. Development. 2000 Jun;127(11):2317-22
• All: 3 reference(s)